Welcome to the Mori Lab at the Chinese Institute for Brain Research, Beijing (CIBR). We use the simple yet powerful model organism, Caenorhabditis elegans, to decipher the fundamental principles of neural circuit operation and modulation. Under the direction of Prof. Ikue Mori, a pioneer in the field, the lab’s research is centered on thermotaxis behavior as a model for neural computation. We also pursue complementary projects investigating neuropeptide co-transmission and its role in age-related neural dysfunction.

The Core Circuitry of Thermotaxis

Building on the identification of the neurocircuit underlying temperature navigation (Mori and Ohshima, 1995, Nature), we dissect the complete sensorimotor pathway. We investigate how the circuit performs core computations—such as signal integration and gating between neurons like the AFD thermosensor and AIY interneuron—to translate sensory input into navigational action.

Neuropeptide Signaling in Circuit Modulation & Dysfunction

Neuropeptides are universal modulators of neural circuit function and behavior. Our lab investigates their roles through two synergistic approaches:

·      Aging, Thermoregulation, and Neurokinin Signaling

We study the breakdown of precise thermotaxis as a model for conserved neural dysfunction. Dysregulation of steroid hormone signaling impairs temperature homeostasis in both C. elegans and aging humans, and this impairment is mediated by the disruption of neurokinin signaling—a key neuropeptide pathway. This parallel establishes a powerful model system to dissect the conserved cellular and circuit mechanisms of failed temperature homeostasis, with direct relevance to age- and menopause-related conditions such as hot flashes.

·      Mechanisms of Neuropeptide Co-transmission

This research stream investigates how neurons achieve precise, independent control over the release of multiple neuropeptides. A major focus is elucidating hierarchical regulatory mechanisms, whereby the release of one neuropeptide species is controlled via the autocrine signaling of another (Aoki et al., 2024, Nat. Commun.). This project addresses the fundamental question of how neuropeptidergic co-transmission is orchestrated to fine-tune neural circuit output.

Unifying Elements & Techniques

These research themes are united by a deep focus on C. elegans neurobiology and a shared methodological toolkit and knowledgebase:

·      Advanced genetics, including CRISPR/Cas9 genome editing and transgenesis.

·      In vivo functional imaging (calcium, voltage, neuropeptide release).

·      Quantitative behavioral analysis and optogenetics.

·      Gene expression profile in individual neurons.

·      Anatomical, functional and neuropeptidergic connectomes.