Publications

(* corresponding author)

Peer-reviewed papers:

2026

Tanaka M, Tsukada S, Jang MS, Aleogho BM, Mori I * Kentaro Noma (2026) Lactobacillus paragasseri ameliorates age-dependent thermotaxis decline in Caenorhabditis elegans. Scientific Reports 16, 17934.

2025

Nakayama A, Kuroyanagi H, Matsuyama HJ, Mori I, Hisamoto N, *Nakano S (2025) A multilayered gap junction network is essential for social decision- making. Proc. Natl. Acad. Sci. U. S. A. 122(41). e2510579122.

Aleogho BM, Mohri M, Jang MS, Tsukada S, Al-Hebri Y, Matsuyama HJ, Tsukada Y, Mori I, * Noma K(2025) Aberrant neuronal hyperactivation causes an age-dependent behavioral decline in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 122(1). e2412391122.

2024

Nakayama A, Watanabe M, Yamashiro R, Kuroyanagi H, Matsuyama HJ, Oshima A, Mori I, * Nakano S (2024). A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 121(21). e2406565121.

Suryawinata N, Yokosawa R, Tan KHC, Lai AL, Sone R, Mori I, *Noma K (2024). Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans. Scientific Reports 14(1), 5529.

2022

Aoki I, Jurado P, Nawa K, Kondo R, Yamashiro R, Matsuyama HJ, Ferrer I, Nakano S & Mori I (2022). OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans. PLOS Genetics June 8, 2022, https://doi.org/10.1371/journal.pgen.1010219

2020

Huang TT, Matsuyama HJ, Tsukada Y, Singhvi A, Syu RT, Lu Y, Shaham S, *Mori I & *Pan CL (2020) “Age-dependent changes in response property and morphology of a thermosensory neuron and thermotaxis behavior in Caenorhabditis elegans” Aging Cell 19.

Matsuyama HJ & *Mori I (2020) “Neural Coding of Thermal Preferences in the Nematode Caenorhabditis elegans” eNeuro 7, ENEURO.0414-19.2020.

Nakano S, Ikeda M, Tsukada Y, Fei X, Suzuki T, Niino Y, Ahluwalia R, Sano A, Kondo R, Ihara K, Miyawaki A, Hashimoto K, Higashiyama T & *Mori I (2020) “Presynaptic MAST kinase controls opposing postsynaptic responses to convey stimulus valence in Caenorhabditis elegans” Proc. Natl. Acad. Sci. U. S. A. 117, 1638–1647.

Ikeda M, Nakano S, Giles AC, Xu L, Costa WS, Gottschalk A & *Mori I (2020) “Context-dependent operation of neural circuits underlies a navigation behavior in Caenorhabditis elegans” Proc. Natl. Acad. Sci. U. S. A. 117, 6178–6188.

Tsukamoto S, Emmei T, Nakano S, Nishio N, Sasakura H & *Mori I (2020) “The Caenorhabditis elegans INX-4/Innexin is required for the fine-tuning of temperature orientation in thermotaxis behavior” Genes to Cells 25, 154–164.

2019

Ikenaka K, Tsukada Y, Giles AC, Arai T, Nakadera Y, Nakano S, Kawai K, Mochizuki H, Katsuno M, Sobue G & *Mori I (2019) “A behavior-based drug screening system using a Caenorhabditis elegans model of motor neuron disease” Sci. Rep. 9.

An SWA, Choi ES, Hwang W, Son HG, Yang JS, Seo K, Nam HJ, Nguyen NTH, Kim EJE, Suh BK, Kim Y, Nakano S, Ryu Y, Man Ha C, Mori I, Park SK, Yoo JY, Kim S & *Lee SJ V. (2019) “KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain” Aging Cell 18.

2018

Aoki I, Tateyama M, Shimomura T, Ihara K, Kubo Y, Nakano S & *Mori I (2018) “SLO potassium channels antagonize premature decision making in C. elegans” Commun. Biol. 1, 123.

Yamaguchi S, *Naoki H, Ikeda M, Tsukada Y, Nakano S, Mori I & Ishii S (2018) “Identification of animal behavioral strategies by inverse reinforcement learning” PLoS Comput. Biol. 14.

2017

*Sasakura H, Moribe H, Nakano M, Ikemoto K, Takeuchi K & *Mori I (2017) “Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans” J. Cell Sci. 130, 2631–2643.

Taniguchi A, Kimura Y, Mori I, Nonaka S & *Higashijima SI (2017) “Axially-confined in vivo single-cell labeling by primed conversion using blue and red lasers with conventional confocal microscopes” Dev. Growth Differ. 59, 741–748.

2016

Kobayashi K, Nakano S, Amano M, Tsuboi D, Nishioka T, Ikeda S, Yokoyama G, Kaibuchi K & *Mori I (2016) “Single-Cell Memory Regulates a Neural Circuit for Sensory Behavior” Cell Rep. 14, 11–21.

Tsukada Y, Yamao M, Naoki H, Shimowada T, Ohnishi N, Kuhara A, Ishii S & *Mori I (2016) “Reconstruction of spatial thermal gradient encoded in thermosensory neuron AFD in Caenorhabditis elegans” J. Neurosci. 36, 2571–2581.

Yoshida A, Nakano S, Suzuki T, Ihara K, Higashiyama T & *Mori I (2016) “A glial K+/Cl-cotransporter modifies temperature-evoked dynamics in Caenorhabditis elegans sensory neurons” Genes, Brain Behav. 15, 429–440.

2015

*Yoshinari Y, Mori S, Igarashi R, Sugi T, Yokota H, Ikeda K, Sumiya H, Mori I, Tochio H, *Harada Y & Shirakawa M (2015) “Optically detected magnetic resonance of nanodiamonds in vivo; implementation of selective imaging and fast sampling” J. Nanosci. Nanotechnol. 15, 1014–1021.

*Fujiwara M, Hino T, Miyamoto R, Inada H, Mori I, Koga M, Miyahara K, Ohshima Y & Ishihara T (2015) “The importance of cGMP signaling in sensory cilia for body size regulation in Caenorhabditis elegans” Genetics 201, 1497–1510.

2013

Ikenaka K, Kawai K, Katsuno M, Huang Z, Jiang YM, Iguchi Y, Kobayashi K, Kimata T, Waza M, Tanaka F, Mori I & *Sobue G (2013) “dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration” PLoS One 8.

*Ohnishi T, Tanizawa Y, Watanabe A, Nakamura T, Ohba H, Hirata H, Kaneda C, Iwayama Y, Arimoto T, Watanabe K, Mori I & Yoshikawa T (2013) “Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: Functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes” J. Neurochem. 124, 685–694.

2012

Kimata T, Tanizawa Y, Can Y, Ikeda S, Kuhara A & *Mori I (2012) “Synaptic polarity depends on phosphatidylinositol signaling regulated by myo-inositol monophosphatase in Caenorhabditis elegans” Genetics 191, 509–521.

Igarashi R, Yoshinari Y, Yokota H, Sugi T, Sugihara F, Ikeda K, Sumiya H, Tsuji S, Mori I, Tochio H, *Harada Y & *Shirakawa M (2012) “Real-time background-free selective imaging of fluorescent nanodiamonds in vivo” Nano Lett. 12, 5726–5732.

Nishio N, Mohri-Shiomi A, Nishida Y, Hiramatsu N, Kodama-Namba E, Kimura KD, Kuhara A & *Mori I (2012) “A novel and conserved protein AHO-3 is required for thermotactic plasticity associated with feeding states in Caenorhabditis elegans” Genes to Cells 17, 365–386.

2011

Aoki R, Yagami T, Sasakura H, Ogura KI, Kajihara Y, Ibi M, Miyamae T, Nakamura F, Asakura T, Kanai Y, Misu Y, Iino Y, Ezcurra M, Schafer WR, Mori I & *Goshima Y (2011) “A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans” J. Neurosci. 31, 16603–16610.

Kuhara A, Ohnishi N, Shimowada T & *Mori I (2011) “Neural coding in a single sensory neuron controlling opposite seeking behaviours in Caenorhabditis elegans” Nat. Commun. 2, 355–359.

Miyara A, Ohta A, Okochi Y, Tsukada Y, Kuhara A & *Mori I (2011) “Novel and conserved protein macoilin is required for diverse neuronal functions in Caenorhabditis elegans” PLoS Genet. 7.

Nishida Y, Sugi T, Nonomura M & *Mori I (2011) “Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis” EMBO Rep. 12, 855–862.

Ohnishi N, Kuhara A, Nakamura F, Okochi Y & *Mori I (2011) “Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans” EMBO J. 30, 1376–1388.

Sugi T, Nishida Y & *Mori I (2011) “Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans” Nat. Neurosci. 14, 984–992.

2010

Adachi T, Kunitomo H, Tomioka M, Ohno H, Okochi Y, Mori I & *Iino Y (2010) “Reversal of salt preference is directed by the insulin/PI3K and G q/PKC signaling in Caenorhabditis elegans” Genetics 186, 1309–1319.

Jurado P, Kodama E, Tanizawa Y & *Mori I (2010) “Distinct thermal migration behaviors in response to different thermal gradients in Caenorhabditis elegans” Genes, Brain Behav. 9, 120–127.

Liu J, Ward A, Gao J, Dong Y, Nishio N, Inada H, Kang L, Yu Y, Ma D, Xu T, Mori I, Xie Z & *Xu XZS (2010) “C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog” Nat. Neurosci. 13, 715–722.

2008

Kuhara A, Okumura M, Kimata T, Tanizawa Y, Takano R, Kimura KD, Inada H, Matsumoto K & *Mori I (2008) “Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans” Science 320, 803–807.

2006

Kodama E, Kuhara A, Mohri-Shiomi A, Kimura KD, Okumura M, Tomioka M, Iino Y & *Mori I (2006) “Insulin-like signaling and the neural circuit for integrative behavior in C. elegans” Genes Dev. 20, 2955–2960.

*Inada H, Ito H, Satterlee J, Sengupta P, Matsumoto K & Mori I (2006) “Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans” Genetics 172, 2239–2252.

Ito H, Inada H & *Mori I (2006) “Quantitative analysis of thermotaxis in the nematode Caenorhabditis elegans” J. Neurosci. Methods 154, 45–52.

*Kuhara A & *Mori I (2006) “Molecular physiology of the neural circuit for calcineurin-dependent associative learning in Caenorhabditis elegans” J. Neurosci. 26, 9355–9364.

Tanizawa Y, Kuhara A, Inada H, Kodama E, Mizuno T & *Mori I (2006) “Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans” Genes Dev. 20, 3296–3310.

2005

Mohri A, Kodama E, Kimura KD, Koike M, Mizuno T & *Mori I (2005) “Genetic control of temperature preference in the nematode Caenorhabditis elegans” Genetics 169, 1437–1450.

Okochi Y, Kimura KD, Ohta A & *Mori I (2005) “Diverse regulation of sensory signaling by C. elegans nPKC-epsilon/eta TTX-4” EMBO J. 24, 2127–2137.

Sasakura H, Inada H, Kuhara A, Fusaoka E, Takemoto D, Takeuchi K & *Mori I (2005) “Maintenance of neuronal positions in organized ganglia by SAX-7, a Caenorhabditis elegans homologue of L1” EMBO J. 24, 1477–1488.

2004

*Kimura KD, Miyawaki A, Matsumoto K & *Mori I (2004) “The C. elegans Thermosensory Neuron AFD Responds to Warming” Curr. Biol. 14, 1291–1295.

Shimozono S, Fukano T, Kimura KD, Mori I, Kirino Y & *Miyawaki A (2004) “Slow Ca2+ dynamics in pharyngeal muscles in Caenorhabditis elegans during fast pumping” EMBO Rep. 5, 521–526.

2002

*Ishihara T, Iino Y, Mohri A, Mori I, Gengyo-Ando K, Mitani S & Katsura I (2002) “HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans” Cell 109, 639–649.

Kuhara A, Inada H, Katsura I & *Mori I (2002) “Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6” Neuron 33, 751–763.

2001

Gomez M, De Castro E, Guarin E, Sasakura H, Kuhara A, Mori I, Bartfai T, Bargmann CI & *Nef P (2001) “Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans” Neuron 30, 241–248.

Satterlee JS, Sasakura H, Kuhara A, Berkeley M, Mori I & *Sengupta P (2001) “Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd/Otx” Neuron 31, 943–956.

1999

Komatsu H, Jin YH, L’Etoile N, Mori I, Bargmann CI, Akaike N & *Ohshima Y (1999) “Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells” Brain Res. 821, 160–168.

1998

Coburn CM, Mori I, Ohshima Y & *Bargmann CI (1998) “A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: A distinct pathway for maintenance of sensory axon structure” Development 125, 249–258.

1997

Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y & *Ruvkun G (1997) “Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene” Neuron 19, 345–357.

1996

Komatsu H, Mori I, Rhee JS, Akaike N & *Ohshima Y (1996) “Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans” Neuron 17, 707–718.

1995

*Mori I & Ohshima Y (1995) “Neural regulation of thermotaxis in Caenorhabditis elegans” Nature 376, 344–348.

1994

Ogura KI, Wicky C, Magnenat L, Tobler H, Mori I, Müller F & *Ohshima Y (1994) “Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase” Genes Dev. 8, 2389–2400.

1990

Mori I, Moerman DG & *Waterston RH (1990) “Interstrain crosses enhance excision of Tc1 transposable elements in Caenorhabditis elegans” MGG Mol. Gen. Genet. 220, 251–255.

1988

Mori I, Benian GM, Moerman DG & *Waterston RH (1988) “Transposable element Tc1 of Caenorhabditis elegans recognizes specific target sequences for integration” Proc. Natl. Acad. Sci. U. S. A. 85, 861–864.

Mori I, Moerman DG & *Waterston RH (1988) “Analysis of a mutator activity necessary for germline transposition and excision of Tc1 transposable elements in Caenorhabditis elegans” Genetics 120, 397–407.

1987

DeSalle R, Templeton A, Mori I, Pletscher S & *Johnston JS (1987) “Temporal and spatial heterogeneity of mtDNA polymorphisms in natural populations of Drosophila mercatorum” Genetics 116, 215–223.

1985

Charlesworth B, Mori I & *Charlesworth D (1985) “Genetic variation in recombination in drosophila. Iii. regional effects on crossing over and effects on non-disjunction” Heredity (Edinb). 55, 209–221.